You can use a product with matrixyl and argireline (think those are the names), which are peptides, and they can make a significant difference on wrinkles. If your situation is such that it doesn't require such intense measures, use a good serum and moisturizer with antioxidants and hyaluronic acid, apply a lipliner before lipstick or gloss to prevent bleeding, and if that's not enough, try something like Cargo Reverse lipliner around the perimeter of the lip to further prevent bleeding.